In 1855, another appeal reached Emmitsburg, this time from Bishop Amat of Monterey (Los Angeles) who knew the great good that could be done in his diocese and who was anxious to have the sisters assist him in caring for and instructing the children. Emmitsburg responded to this appeal and named Sisters Scholastica Logsden and Ann Gillen for Los Angeles. Bishop Amat had already recruited three young women in Spain who became Daughters of Charity and were also named for Los Angeles. They were Angelita Mombrado, Clara de Cisneros and Francesca Fernandez.

These five sisters (accompanied by Bishop Amat) boarded a steamer and sailed from New York to Panama on October 20, 1855. They arrived on the Atlantic side and crossed the Isthmus in rail cars. When they reached the Pacific side, they boarded another steamer and sailed on to San Francisco where they arrived 25 days after their departure from New York. They were received by their sisters who had preceded them to California. After several weeks in San Francisco, these five sisters (and Sister Corsina McKay from San Francisco) continued their journey to Los Angeles. They boarded a smaller steamer and sailed on to San Pedro where they arrived on January 6, 1856.

Sister Scholastica Logsden was the leader of this colony of sisters in Los Angeles. Here, they established an orphanage and school and then an infirmary.

The Daughters of Charity have provided more than 150 years of continuing service to the people of Los Angeles.